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The mechanochemical enzyme dynamin is the ‘wire-puller’ that mediates the uptake of nutrients into the cell. However, pathogens also utilize this means to enter the interior of the cell. (A) MDC researchers were able to elucidate the molecular structure of dynamin. If the cell membrane containing the cargo molecules invaginates inward – a process called endocytosis – dynamin self-assembles around the neck of the vesicle in a spiral. (B) Driven by the energy of the cell’s GTP, the vesicle neck is constricted and the vesicle is then pinched off from the cell membrane.
(Graphik: Dr. Katja Fälber and M.Sc. Bioinf. Martin Held/Copyright: MDC)
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