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Nachrichten, Termine, Experten
Nachrichten, Termine, Experten
Abb. A, in einem Nierenzellkarzinom mit einem Defekt im "von Hippel-Lindau"-Gen ist der "Hypoxie-induzierbare Faktor" (HIF) in praktisch allen Tumorzellkernen nachweisbar (rot angefärbt), unabhängig von der Sauerstoffversorgung der Zellen. Die gestrichelte Linie markiert die Grenze des Tumors, links davon Bindegewebe. Abb. B, das angrenzende Nierengewebe ist geschädigt, zeigt aber keine HIF-Aktivierung. Pfeile markieren zwei Nierenkörperchen (Glomeruli).
Bildquelle: Warnecke/Wiesener
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