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Scientists working with Prof Jan Rossaint and Prof Alexander Zarbock, two anesthesiologists and intensive care specialists at the University of Münster, have found how platelets interacting with white blood cells contribute to the resolution of bacterial lung inflammation in mice. The results may help in the search for therapies to specifically regulate inflammation.
Treating patients with acute respiratory failure is a constant challenge in intensive care medicine. In most cases, the underlying cause is lung inflammation triggered by a bacterial infection or – more rarely, despite being frequently observed at present due to the corona pandemic – a viral infection. During the inflammation, cells of the immune system – the white blood cells – migrate to the lungs and fight the pathogens. At the same time, however, they also cause “collateral damage” in the lung tissue. If the inflammatory reaction is not resolved in time, this can result in chronic inflammation with permanent impairment of lung function. Together with colleagues from London, Madrid and Munich, a research team at the University of Münster headed by Prof Jan Rossaint and Prof Alexander Zarbock, two specialists in anaesthesiology and intensive care medicine, has gained new insight into the cellular processes involved in bacterial lung inflammation. In a study on mice, the researchers found that the interaction between platelets and certain white blood cells – the regulatory T cells – play a significant role in resolving the inflammation. The study has been published in the Journal of Experimental Medicine.
Platelets partner with regulatory T cells and send signals to scavenger cells
It was already known that, at the beginning of an inflammatory reaction in the lungs, as is the case with other organs, platelets work together with neutrophil granulocytes – a subgroup of white blood cells that specialize in fighting off pathogens. However, for the first time, the team of scientists has now shown that, as the inflammation progresses, platelets bind to regulatory T cells and that this binding is needed for the migration of the T cells, together with the platelets, to the site of inflammation in the lungs. Upon their arrival, they work together secreting anti-inflammatory messenger substances which “reprogramme” the macrophages in the lungs. These white blood cells, also known as scavenger cells, then stop directing neutrophil granulocytes to the site of inflammation, instead eliminating the neutrophil granulocytes that are no longer needed. This helps the inflammation subside and prevents further tissue damage.
Search for new therapy concepts
“When treating patients with acute lung failure, we have various measures we can take to support lung function and focus on combating the causative pathogens with antibiotics, for example,” explains Jan Rossaint. “However, we lack other therapeutic options which can be used to target the causes and regulate the course of the inflammation.” These latest investigations have provided a basis for such therapy concepts. In further steps, the researchers will examine whether the inflammatory mechanisms they observed in mice also occur in humans and look for starting points to test specific therapies.
Funding
This study was funded by the German Research Foundation, i.a. within the framework of the Clinical Research Unit 342 “Organ Dysfunction During Systemic Inflammation” at the University of Münster, and received further financial support from the German-Israeli Foundation for Scientific Research and Development.
Prof. Dr. Jan Rossaint
rossaint@uni-muenster.de
Tel.: +49 251 83-47256 (Nicole Finocchiaro)
Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A. Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med (2021) 218 (7): e20201353. Doi: 10.1084/jem.20201353
https://www.ukm.de/index.php?id=11027 Research group of Prof Dr Jan Rossaint
https://www.ukm.de/index.php?id=11229 Research group of Prof Dr Alexander Zarbock
https://kfo342.de/en/ Clinical Research Unit 342 “Organ Dysfunction During Systemic Inflammation” at the University of Münster
Platelets (red) interacting with regulatory T cells (yellow) in the bacterially inflamed lung tissue ...
Rossaint et al./JExpMed 2021
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