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Molecular mechanisms of post-transcriptional gene regulation will be studied
Dr. Julian König has been appointed as a Group Leader at the Institute of Molecular Biology (IMB). He will study RNA biology, with a particular focus on the molecular mechanisms of post-transcriptional gene regulation, using a variety of high-throughput sequencing-based technologies.
Humans contain a huge diversity of proteins. Alternative splicing is the key mechanism by which cells generate this diversity. Dr. Julian König will investigate how protein-networks act to regulate this process. One of Dr. König's major interests is the splicing of transposable elements. This is a common cause of genetic disease and, at the same time, also considered an important driving force of primate evolution. To study protein-RNA interactions König uses a number of genome-wide approaches that provide us with a systemic understanding of the molecular mechanisms in action. Methods used in his lab include RNA-seq and novel methods that he has developed such as iCLIP.
Before joining IMB, Dr. Julian König worked in the group of Prof. Dr Jernej Ule at the renowned Laboratory of Molecular Biology in Cambridge, UK. Here he developed the iCLIP technology and discovered a general mechanism that protects the human transcriptome against the erroneous splicing of transposable elements.
With his expertise of high-throughput sequencing-based RNA tools, Dr König’s lab will complement the research portfolio of IMB.
Further details:
Further information about Dr. Julian König’s research can be found at www.imb-mainz.de/research/koenig/.
The Institute for Molecular Biology gGmbH (IMB)
The Institute of Molecular Biology gGmbH (IMB) is a new center of excellence in the life sciences which was established in March 2011. Research at IMB concentrates on three cutting-edge areas: epigenetics, developmental biology and DNA repair. The institute is a prime example of a successful collaboration between public authorities and a private foundation. The Boehringer Ingelheim Foundation has dedicated EUR 100 million for a period of 10 years to cover the operating costs for research at IMB, while the state of Rhineland-Palatinate provided approximately EUR 50 million for the construction of a state-of-the-art building. For more information about IMB please visit www.imb-mainz.de.
The Boehringer Ingelheim Foundation
The Boehringer Ingelheim Foundation is an independent, non-profit organization committed to the promotion of the medical, biological, chemical, and pharmaceutical sciences. It was established in 1977 by Hubertus Liebrecht (1931-1991), a member of the shareholder family of the company Boehringer Ingelheim. With the “PLUS 3” Perspectives Program and the Exploration Grants, the foundation supports independent group leaders, it endows the internationally renowned Heinrich Wieland Prize as well as awards for up-and-coming scientists. In addition, the foundation has endowed EUR 100 million over a period of ten years to finance the scientific running of the Institute of Molecular Biology (IMB) at Mainz University. For more information about the foundation and its programs, please visit www.boehringer-ingelheim-stiftung.de.
Press contact for further information:
Dr Ralf Dahm
Institute of Molecular Biology gGmbH (IMB)
Ackermannweg 4
D 55128 Mainz, GERMANY
phone: +49 6131 39-21455
fax: +49 6131 39-21421
e-mail: press@imb-mainz.de
www.imb-mainz.de
http://www.imb-mainz.de/home/detail/?tx_ttnews%5Btt_news%5D=282&cHash=1142ad... - press release ;
http://www.imb-mainz.de/research/koenig/research/ - Genomic Views of Splicing Regulation
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