idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Grafik: idw-Logo

idw - Informationsdienst


25.10.2011 13:39

Enzyme controlling cell death paves way for treatment of brain damage in newborns

Helena Aaberg Information Office
University of Gothenburg

    Brain damage due to birth asphyxia – where the brain is starved of oxygen around the time of delivery – is normally treated by cooling the infant, but this only helps one baby in nine. New research from the Sahlgrenska Academy at the University of Gothenburg, Sweden, could now pave the way for new ways of treating brain damage in newborns.

    Birth asphyxia can cause irreparable brain damage and lifelong handicaps, including cerebral palsy, epilepsy and mental retardation. The brain damage evolves over a time period of hours to days after the injury. This opens up a therapeutic window where we are able to affect outcome. Birth asphyxia is normally treated by cooling the infant, which has been shown to reduce the risk of lasting problems.

    Saves only one in nine
    Unfortunately this therapy stops only one child in nine from suffering brain damage. Furthermore, premature babies cannot be treated in this way. In her doctoral thesis, Ylva Carlsson has therefore attempted to find a new treatment strategy that can be used not only in combination with cooling therapy but also to help children where cooling therapy is not an option.

    Mapping the key enzyme
    The focus is on an enzyme which controls elements of the apoptosis – cell death – associated with the brain damage.
    "We’ve mapped the role this enzyme plays in the development of brain damage in newborns who suffer from birth asphyxia," says Carlsson. "The results show that a reduction in the amount of this enzyme also reduces the extent of the brain damage. Added protection is given if cooling therapy is used too."

    Age affects brain damage
    Based on a study of mice, Carlsson is also able to show in her thesis that the mechanisms behind brain damage vary according to the age of the brain: a treatment that can protect adults turned out to exacerbate the damage in newborns.

    Tailor-made treatments
    "This may mean that some drugs developed for brain damage in adults should probably not be given to newborn babies," says Carlsson. "Tailor-made treatments targeting specific brain damage mechanisms and combination treatments for children may therefore be the way forward. But first we need to look more closely at how best to control these proteins without disrupting other key functions in the growing brain."

    For more information, please contact: Ylva Carlsson
    Mobile: +46 (0)703 641 240

    Merkmale dieser Pressemitteilung:
    Journalisten, Lehrer/Schüler, Studierende, Wissenschaftler, jedermann
    Forschungsergebnisse, Forschungsprojekte


    Die Suche / Erweiterte Suche im idw-Archiv

    Sie können Suchbegriffe mit und, oder und / oder nicht verknüpfen, z. B. Philo nicht logie.


    Verknüpfungen können Sie mit Klammern voneinander trennen, z. B. (Philo nicht logie) oder (Psycho und logie).


    Zusammenhängende Worte werden als Wortgruppe gesucht, wenn Sie sie in Anführungsstriche setzen, z. B. „Bundesrepublik Deutschland“.


    Die Erweiterte Suche können Sie auch nutzen, ohne Suchbegriffe einzugeben. Sie orientiert sich dann an den Kriterien, die Sie ausgewählt haben (z. B. nach dem Land oder dem Sachgebiet).

    Haben Sie in einer Kategorie kein Kriterium ausgewählt, wird die gesamte Kategorie durchsucht (z.B. alle Sachgebiete oder alle Länder).