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• Evonik is conducting research on new composite materials for the fixation of fractured bones
• Bioresorbable polymers degrade naturally in the body, eliminating the need for additional surgery
• Medical implant technology is an attractive and growing market
Evonik is conducting cutting-edge research into biodegradable high-strength composites. These materials could potentially replace metal in implants used for the internal fixation of fractured bones. Implants play a key role in supporting bones until they heal. Today’s metallic devices typically remain in the body for the rest of the patient’s life or require additional surgery for removal. By contrast, devices made with Evonik’s new composites will be absorbed by the body gradually once the bone healing process has taken place. These materials consist of polymers and of substances that naturally occur in bones. Evonik’s research is still in its early stages – however, the possible benefits for patients are already clear. Patients will no longer need to undergo additional surgical procedures to remove the implanted devices. Specific device designs may also help bones regenerate faster.
The project is one of a number currently being conducted at the Medical Devices Project House in Birmingham, Alabama, USA, which employs a team of more than 20 experts. Its mission is to develop new medical technology solutions and materials, with a particular emphasis on implants. Dr. Andreas Karau, Head of the Project House, explains the researchers’ vision: “In the long term, our focus is regenerative medicine. We want to create bioabsorbable implants to replace damaged tissues with healthy tissues. Our current work on biodegradable composites is a first step in this direction.”
There is a significant need for high-strength biodegradable materials. The number of implants required for the fixation of bone fractures is substantial: osteoporosis, for example, is responsible for 8.9 million fractures every year. Additionally, the 300 billion-euro global medical technology market is growing at around six percent annually. The USA commands the largest share of the global market by far, with 40 percent. Moreover, American companies are major players in implant technology. Other key medical technology markets include Europe and Japan.
“Our leading position in polylactic acid-based polymers is an excellent foundation for the development of materials and solutions for regenerative medicine,” explains Karau. The polymers break down into carbon dioxide and water. Degradation time depends on their molecular composition, chain length, and crystallinity. They can last from a few weeks to many months – providing plenty of time for bones or other tissues to regenerate.
Medical device manufacturers use RESOMER® polymers marketed by Evonik’s Health Care Business Line to make bioabsorbable screws, pins and small plates. These are primarily used for torn ligaments in the knee or shoulder, and for fixation of smaller bones in fingers or the face.
However, as Karau notes, “At the moment, the materials we have available are not strong enough to be used for large, load-bearing bones.” Consequently, the researchers at Medical Devices Project House are exploring composite materials that reinforce biodegradable polymers with inorganic substances, such as derivatives of calcium phosphate. Not only do these additives strengthen the material, they enhance its biocompatibility. “As the polymers gradually break down, calcium and phosphate can be absorbed into the newly formed bone tissue,” Karau explains.
Moreover, the researchers’ vision goes even further. With the right materials, they could harness 3D printing to create made-to- measure implants for individual patients. One of the goals of Evonik’s researchers in Birmingham is to make its biodegradable polymers suitable for this additive manufacturing process.
Karau adds: “In the long term, we intend to develop polymeric scaffolds that could be colonized with living cells – creating a true biological implant.” This approach would make it possible to regenerate cartilage, for example – or to replace damaged heart tissue with healthy tissue. However, the researchers must first find ways to improve the materials’ biocompatibility.
The scientific experts in Birmingham are part of Creavis, Evonik’s strategic innovation unit, and work hand-in-glove with polymer specialists from the Health Care and Performance Materials Business Lines. The team at the Project House is also investigating biocompatible plastics, used in Evonik’s VESTAKEEP® Implant product line. Currently, Evonik’s medical technology portfolio comprises RESOMER® and VESTAKEEP® Implant materials, and VESTAMID® Care – polyamide resins used for molding catheters and similar items.
Creavis Project Houses typically concentrate on a defined field for a period of three years, and collaborate with multiple Business Lines. Once the project draws to a close, the researchers return to their respective Business Lines – one of which markets the resulting products and technologies. Since 2000, Evonik has established a total of eleven Project Houses.
Company information
Evonik, the creative industrial group from Germany, is one of the world leaders in specialty chemicals. Profitable growth and a sustained increase in the value of the company form the heart of Evonik’s corporate strategy. Its activities focus on the key megatrends health, nutrition, resource efficiency and globalization. Evonik benefits specifically from its innovative prowess and integrated technology platforms.
Evonik is active in over 100 countries around the world. In fiscal 2015 more than 33,500 employees generated sales of around €13.5 billion and an operating profit (adjusted EBITDA) of about €2.47 billion.
About Nutrition & Care
The Nutrition & Care segment is led by Evonik Nutrition & Care GmbH and contributes to fulfilling basic human needs. That includes applications for everyday consumer goods as well as animal nutrition and health care. This segment employed about 7,000 employees, and generated sales of around €4.9 billion in 2015.
Disclaimer
In so far as forecasts or expectations are expressed in this press release or where our statements concern the future, these forecasts, expectations or statements may involve known or unknown risks and uncertainties. Actual results or developments may vary, depending on changes in the operating environment.
Neither Evonik Industries AG nor its group companies assume an obligation to update the forecasts, expectations or statements contained in this release.
In the Medical Devices Project House in Birmingham (Alabama, USA) Evonik is developing improved mate ...
Evonik Industries AG
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In the Medical Devices Project House in Birmingham (Alabama, USA) Evonik is developing improved mate ...
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