idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Grafik: idw-Logo

idw - Informationsdienst
Wissenschaft

Science Video Project
idw-Abo

idw-News App:

AppStore

Google Play Store



Instanz:
Teilen: 
22.02.2018 09:37

FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation

Dr. Susanne Langer Kommunikation und Presse
Friedrich-Alexander-Universität Erlangen-Nürnberg

    Inflammation needs energy: An important source for this energy is oxygen, which is indispensable for the cells of the immune system to work properly. On the one hand, oxygen is an essential element required for cells to survive; on the other hand, it also adds fuel to the fire of inflammation. Researchers from Department of Medicine 3 – Rheumatology and Immunology at Universitätsklinikum Erlangen at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have discovered that the body skilfully uses this process to extinguish inflammation. Immune cells are tricked into believing that they are lacking oxygen, leading them to retreat from the site of the inflammation in order to save energy.

    Oxygen levels within the body are monitored closely. Oxygen sensors in the body measure the concentration of oxygen in the cells. The sensors are activated whenever oxygen levels fall, for example if less is available or more is consumed. The most important oxygen sensor in the body is a protein named hypoxia-inducible factor, HIF for short, which is activated when oxygen levels dip.

    Prof. Dr. Aline Bozec from Department of Medicine 3 – Rheumatology and Immunology (director: Prof. Dr. Georg Schett) at Universitätsklinikum Erlangen was able to demonstrate that increased activation of HIF-1α in immune cells led to a reduction in inflammation. This new research has shed light on a molecular mechanism which keeps serious inflammatory diseases of the human body such as arthritis and multiple sclerosis in check.

    ‘HIF basically acts like a psychotherapist for a certain type of immune cells, the B-lymphocytes,’ explains Professor Bozec. Under the influence of HIF, B-lymphocytes, which usually have a crucial role to play in the excessive immune response, start to produce the regulating messenger substance Interleukin 10, inhibiting the inflammatory process. By activating HIF, B-lymphocytes seem to switch their allegiance.

    The team led by Professor Bozec turned off the oxygen sensor HIF in B cells and observed that this prevented the resolution of inflammation, leading to chronic inflammatory diseases. The results pave the way for new approaches for treating chronic inflammatory diseases such as arthritis or multiple sclerosis using medication to turn off HIF. The work of Professor Bozec is supported by the collaborative research centre 1181: Checkpoints for Resolution of Inflammation.

    The findings have been published in the journal Nature Communications (DOI: 10.1038/s41467-017-02683-x).

    Contact:
    Prof. Dr. Aline Bozec
    Phone: 09131 85 29032
    aline.bozec@uk-erlangen.de


    Bilder

    Merkmale dieser Pressemitteilung:
    Journalisten
    Medizin
    überregional
    Forschungsergebnisse, Forschungsprojekte
    Englisch


     

    Hilfe

    Die Suche / Erweiterte Suche im idw-Archiv
    Verknüpfungen

    Sie können Suchbegriffe mit und, oder und / oder nicht verknüpfen, z. B. Philo nicht logie.

    Klammern

    Verknüpfungen können Sie mit Klammern voneinander trennen, z. B. (Philo nicht logie) oder (Psycho und logie).

    Wortgruppen

    Zusammenhängende Worte werden als Wortgruppe gesucht, wenn Sie sie in Anführungsstriche setzen, z. B. „Bundesrepublik Deutschland“.

    Auswahlkriterien

    Die Erweiterte Suche können Sie auch nutzen, ohne Suchbegriffe einzugeben. Sie orientiert sich dann an den Kriterien, die Sie ausgewählt haben (z. B. nach dem Land oder dem Sachgebiet).

    Haben Sie in einer Kategorie kein Kriterium ausgewählt, wird die gesamte Kategorie durchsucht (z.B. alle Sachgebiete oder alle Länder).