idw – Informationsdienst Wissenschaft

Nachrichten, Termine, Experten

Grafik: idw-Logo
Grafik: idw-Logo

idw - Informationsdienst
Wissenschaft

Science Video Project
idw-Abo

idw-News App:

AppStore

Google Play Store



Instanz:
Teilen: 
21.04.2022 13:40

Can a messenger substance considered to be inflammatory alleviate asthma symptoms?

Blandina Mangelkramer Presse und Kommunikation
Friedrich-Alexander-Universität Erlangen-Nürnberg

    The messenger substance interleukin-3 produced by the body was previously considered to be pro-inflammatory in bronchial asthma. A research team from Universitätsklinikum Erlangen has now shown for the first time that the administration of interleukin-3, or IL-3 for short, can have a positive effect on chronic inflammatory respiratory disease.

    Members of the research group led by Prof. Susetta Finotto, MD, and doctoral candidate and pharmacist Susanne Krammer from the Department of Molecular Pneumology investigated the production of the messenger substance in healthy preschool children and those affected by asthma who had participated in the European PreDicta pediatric asthma study. They found that children whose asthma was considered controlled by inhaled corticosteroid therapy had higher IL-3 production caused by blood cells known as activated peripheral blood lymphocytes. There was also a positive correlation between IL-3 in nasal fluid and the anti-inflammatory soluble form of the ST2 receptor. This suggests that IL-3 may contribute to alleviating asthma.

    Using mice models induced with asthma, the researchers also investigated whether intranasal administration of IL-3 during asthma provocation could actually improve asthma symptoms. They discovered that IL-3 has a regulatory effect on the immune system and induces certain immune cells called regulatory T cells, which are believed to play a role in relieving bronchial asthma. Administration of IL-3 also decreased the number of pro-inflammatory eosinophil cells and reduced mucus production in the lungs of asthmatic mice.

    IL-3 also resulted in decreased activation of inflammatory innate lymphoid type 2 cells. These immune cells secrete substances that can participate in the development of allergic diseases. They showed lower cell surface expression of the pro-inflammatory bound receptor ST2, which is important for activation of this cell type, when IL-3 was administered. The research group led by Prof. Finotto and Susanne Krammer have clearly shown that IL-3 also has immunoregulatory properties that can improve symptoms in bronchial asthma.


    Wissenschaftliche Ansprechpartner:

    Prof. Dr. Dr. Susetta Finotto
    Department of Molecular Pneumology
    Phone: +49 9131 85 35883
    susetta.finotto@uk-erlangen.de


    Originalpublikation:

    https://www.frontiersin.org/articles/10.3389/fimmu.2022.821658/full


    Bilder

    Merkmale dieser Pressemitteilung:
    Journalisten
    Medizin
    überregional
    Forschungsergebnisse
    Englisch


     

    Hilfe

    Die Suche / Erweiterte Suche im idw-Archiv
    Verknüpfungen

    Sie können Suchbegriffe mit und, oder und / oder nicht verknüpfen, z. B. Philo nicht logie.

    Klammern

    Verknüpfungen können Sie mit Klammern voneinander trennen, z. B. (Philo nicht logie) oder (Psycho und logie).

    Wortgruppen

    Zusammenhängende Worte werden als Wortgruppe gesucht, wenn Sie sie in Anführungsstriche setzen, z. B. „Bundesrepublik Deutschland“.

    Auswahlkriterien

    Die Erweiterte Suche können Sie auch nutzen, ohne Suchbegriffe einzugeben. Sie orientiert sich dann an den Kriterien, die Sie ausgewählt haben (z. B. nach dem Land oder dem Sachgebiet).

    Haben Sie in einer Kategorie kein Kriterium ausgewählt, wird die gesamte Kategorie durchsucht (z.B. alle Sachgebiete oder alle Länder).